Colorectal carcinoma (CRC) is a heterogeneous disease (CRCs) displaying variable etiology, incidence, pathobiology and related molecular pathways, and most importantly, the outcome varies depending on the location of the tumor. Several studies have been conducted which shed light on differences in overall survival between right-sided (RCRC) and left-sided CRC (LCRC). Likely the differences between RCRC and LCRC are due to complex mechanisms of genetic and epigenetic changes caused by intrinsic and extrinsic factors. Therefore, it is essential to determine the individual variations in biological and molecular characteristics of CRCs and consecutively treat cancer patients in a personalized fashion.

Different liver and biliary tract diseases can be pregnancy-related disorders, or pre-existing, concurrent liver diseases, occur at different time of pregnancy leading to maternal and fetal morbidity and mortality. Viral hepatitis caused morbidity and mortality is significant health care problem. Pregnancy doesn’t affect the progression of viral hepatitis, with mild, aspecific symptoms, except hepatitise E caused high morbidity and mortality, and herpes simplex caused fatal liver failure in the 3^rd trimester of pregnancy. Preterm delivery, complications can occur, but the importance of vertical and perinatal transmission is higher, Cytomegalovirus caused congenital abnormalities are severe. Authors review the knowledge of primary and main non primary hepatotrop viruses, with emphasizing the possibilities of decreasing the risk of perinatal transmission.

The most important goals of the recent therapies of inflammatory bowel disease are to induce and maintain clinical remission and mucosal healing. However, symptoms are frequently inconsistent with endoscopic findings. Serum infliximab and antibody-to-infliximab levels are objective parameters that may have a great role in the therapeutic decision making during maintenance biological therapy. The aims of this thesis were to evaluate the correlation between clinical and endoscopic disease activities of ulcerative colitis defined by activity scores in 100 consecutive patients, to assess the correlation between serum infliximab and antibody-to-infliximab levels, the response to infliximab therapy, and to determine the accuracy of serum drug concentration measurement in the prediction of the long-term clinical response in 48 patients suffer from inflammatory bowel disease. Significant correlation was shown between the clinical activity and mucosal healing (p=0.0012 and p<0.001). In this part of the thesis, we evaluated serum infliximab levels, and found that single measurement of antibody-to-infliximab titers was insufficient for predicting therapeutic response due to transient expression of antibody-to-infliximab, however, using the three points' measurements, significant difference was detected between the adequate and inadequate responder group (5.0% vs. 35.7%; p=0.016). Sensitivity and specificity for predicting the therapeutic response were 85.0% and 71.4% based on the cut-off value of trough level 2.0 mg/ml. Our results showed good correlation between the clinical, endoscopic, and histological activities of UC focusing on the importance of evaluating the endoscopic activity of patients. Simultaneous measurement of serum infliximab level prior to administration of regular infliximab infusion and antibody-to-infliximab titers significantly increase the diagnostic accuracy for the therapeutic decision making in patients with indeterminate response to the therapy.

Aorto-bifemoral bypass can cause gastrointestinal bleeding as a complication even years after the surgery. Aorto-enteral fistula can cause both pulsatile and shocking bleeding. Diagnosis is difficult in both cases. In 2017 during 4 months three patients were admitted to our department because of GI bleeding who had aorto-bifemoral bypass in their history. We should suspect that the cause of bleeding might be a fistula between the graft and the intestine in each patient who underwent aorto-bifemoral bypass surgery.

Introduction: The success of Helicobacter pylori eradication is a challenge for every professional outpatient department. Recently, the success of eradication schemes that have previously been successful has decreased worldwide and in our institute as well. The problem led to new international consensus. We investigated the success of our eradication treatments at our hospital’s gastroenterology outpatient care between 2016–2017.
Method: the results of C14 breath tests –carried out 6 weeks later, after the eradication treatment- have been collected, and combined with appropriate eradication treatments registered in our hospital’s IT system. Results have been evaluated in percentages and controlled by chi-square test.
Results: a total of 247 Helicobacter pylori eradication treatment were made according to the control C14 breath tests (143/2016 and104/2017). The number of successful treatments was 104 (73%) in 2016, 82 (79%) in 2017 and unsuccessful treatments were 39 (27%) in 2016 and 21 (22%) in 2017, respectively. 7-day treatment in 2016 was 98 (69%), in 2017, 68 (65%), and their application dropped by 4% over the two years (p = 0.603). The success / failure rate was 73.5/26.5%, remained unchanged (p = 0.993). 10-day treatments were made in 44 cases (31%) in 2016, and 31 (30%) in 2017, their application rate did not change (p = 0.871). The success within 10-day treatment increased by 14%, and the failure decreased by the same (p = 0.135). The 14-day treatments in 2017 (N = 5) were all successful.
Summary: Our retrospective processing supports the importance of lifting eradication treatments from 7 to 10-14 days, as highlighted by the latest guidelines.

Management of acute gastrointestinal bleeding have remained one of the most important and exciting field of emergency medicine for the last 5 decades all over. The continuous development of drug treatment and endoscopic procedures, and also the improving conditions in Hungarian hospitals, as well as the increasing capacities of emergency ambulances makes it reasonable and useful to recover our knowledge on base of newer guidelines and scientific information in order to further improve everyday practice.